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    • 专利摘要:
    Food supplement for female fertility comprising an association of mio-inositol and d-chiro-inositol, folic acid, selenium, melatonin and the probiotic agents lactobacillus rhamnosus, lactobacillus plantarum and lactobacillus crispatus. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2550521A1
    申请号:ES201531144
    申请日:2015-07-31
    公开日:2015-11-10
    发明作者:Robert COSTILLAS PÉREZ；Ángel DELPUEYO VERNIOL
    申请人:Fertypharm S L；Fertypharm Sl；
    IPC主号:
    专利说明:

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    P201531144
    07-31-2015 DESCRIPTION
    Food supplement for female fertility Field of the Invention
    The present invention relates to the use of probiotics in the composition of food supplements intended to improve female fertility. Background of the invention
    Food Supplements are products whose purpose is to complement a normal diet and consist of concentrated sources of nutrients or other substances that have a nutritional or physiological effect, in simple or combined form. They are marketed in a dosage form, that is, capsules, pills, tablets, pills that must be taken in small unit quantities.
    They are not medicines, they improve the well-being of the person but they do not cure any disease. They are intended for people in good health and not for patients, so they do not need a prescription.
    Among the wide variety of food supplements marketed, we distinguish those aimed at enhancing female fertility, which are generally aimed at improving the quality of oocytes and ovules.
    International patent application WO 03/086080 describes a food supplement that improves the hormonal balance by increasing luteinizing hormone (LH) and the release of progesterone and, therefore, ovulation frequency. It also includes vitamins C and E, green tea, and selenium, antioxidants that help improve overall reproductive health. Another element described is L-arginine, which stimulates the female reproductive organs by improving circulation. Finally, folic acid, vitamins B6 and B12, iron, zinc and magnesium help promote women's fertility.
    French patent FR 0503998 describes a food supplement intended for male and female fertility which includes other Vitamins of group B, zinc in the form of salts or complexes, selenium and unsaturated fatty acids.
    B vitamins during pregnancy influence the development of the nervous system and the formation of the red blood cells of the fetus. Vitamin B2 prevents low birth weight and birth defects. Vitamin B6 is important for the metabolism of amino acids and carbohydrates, it has a fundamental role in the development of the central nervous system and in
    P201531144
    07-31-2015
    the formation of compounds related to hemoglobin, so its intake during pregnancy and lactation prevents neurological and behavioral abnormalities in the newborn. It has also been observed that supplements with vitamin B6 reduce nausea and vomiting during pregnancy. Vitamin B12 prevents neural tube defects in the fetus, as well as spontaneous abortions and preeclampsia during pregnancy.
    Selenium is an essential trace element, which must be ingested with the diet. The organism only needs selenium in small amounts. The main function of Selenium is to contribute to the production of antioxidant enzymes, which play an important role in the prevention of cellular damage.
    Other elements used in food supplements for female fertility are melatonin, folic acid and the myo-inositol and D-Chiro-Inositol isomers.
    Melatonin is a hormone that is found naturally in the body. It is synthesized from tryptophan and is mainly produced in the pineal gland. It participates in a wide variety of cellular, neuroendocrine and neurophysiological processes.
    One of the most outstanding characteristics regarding the synthesis of melatonin is its variability throughout the 24-hour cycle, and its precise response to changes in ambient lighting.
    In the field of fertility, it has been shown that there are several factors that can affect oocyte quality and therefore the result of pregnancy in assisted reproduction cycles. The presence of Melatonin and myo-inositol in the follicular fluid correlates positively with the quality of the oocytes and their maturation.
    Myo-inositol is the isomer of greater biological activity. This compound is important in the composition of membrane lipids. The intake of Mio-inositol has been shown to improve insulin sensitivity, reduce plasma insulin levels and restore ovulation. At the oocyte level, Mio-inositol seems to have a role in its maturation and is a marker of good ovocitary quality.
    D-chiro-Inositol is an important messenger in the transmission of the insulin signal that can be obtained by converting Mio-Inositol, thanks to an enzyme, epimerase.
    D-chiro-inositol has a marked effect on polycystic ovary syndrome, one of the main causes of female infertility.
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    07-31-2015
    Insulin resistance plays a key role in the pathophysiology of Polycystic Ovarian Syndrome. A deficiency in a specific mediator, which contains D-chiro-inositol may contribute to insulin resistance in women with polycystic ovary syndrome.
    Treatment with D-chiro-inositol improves the sensitivity to the effects of insulin on glucose and lipid metabolism, as well as improving clinical and biochemical manifestations.
    The improvement to glucose tolerance allows to reduce serum androgens and improved ovulation. Therefore, D-chiro-inositol therapy has been proven effective for the treatment of polycystic ovarian syndrome, offering metabolic and gynecological benefits and facilitating the reproductive process of women suffering from this syndrome.
    Folic acid is a type of vitamin B group. It is the artificial form of folate found in supplements and foods. Folic acid is water soluble and the remaining amounts are excreted in the urine. Therefore, folic acid does not accumulate in the body, and therefore it is necessary to receive a continuous contribution.
    Folic acid contributes to cell work and tissue growth. Adequate intake of folic acid before and during pregnancy helps prevent certain congenital anomalies, or alterations such as anemia.
    The components of these food supplements have a purpose focused on improving the reproductive process of women, however one of the possible causes of infertility is the action of opportunistic microorganisms such as Escherichia Coli and Gardnerella vaginalis bacteria or the Candida Albicans fungus present in the vaginal area
    No formulations of food supplements intended to improve female fertility that incorporate probiotics have been described. Description of the invention
    The invention relates to a nutritional supplement for female fertility that includes probiotics in order to preserve the female genital medium of microorganisms that can affect the development of oocytes and ovules.
    The new food supplement includes an association of:
    a) A mixture consisting of the isomers Mio-Inositol and D-Chiro-Inositol, Folic acid, Selenium and Melatonin.
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    b) A mixture of probiotic agents consisting of Lactobacillus Rhamnosus, Lactobacillus Plantarum and Lactobacillus Crispatus.
    The first mixture is aimed at improving the quality of oocytes and ovules, while the second is intended to preserve the female genital medium of microorganisms that can affect the development of oocytes and ovules.
    Lactobacilli are frequent microorganisms in the female vaginal flora of healthy women, and comprise 70% of the microorganisms in this tissue. The vagina is a delicate ecosystem, where lactobacilli produce lactic acid, and hydrogen peroxide, in order to protect the vagina from infections of other microorganisms.
    Lactobacillus Plantarum exerts through three different mechanisms, a process that prevents colonization by Escherichia Coli bacteria.
    On the one hand, it excludes E. coli bacteria from the vaginal area, through its presence and sperm adhesion capacity. On the other, it competes with the flora of E. Coli, so it does not allow its growth. Finally, by a physical mechanism, it displaces the colonies of E. coli from the mucosa, since Lactobacillus Plantarum has a greater affinity for the receptors than the bacteria
    E. Coli.
    Lactobacillus Rhamnosus, competes with other opportunistic microorganisms such as the Candida Albicans fungus or Gardnerella vaginalis bacteria. This prebiotic restores the physiological vaginal microflora, inhibiting recurrent vaginal infections that can interfere with a woman's reproductive capacity.
    Lactobacillus Crispatus, which appears dominant in the vaginal mucosa, helps maintain its health status, and generate an essential barrier that contributes to the normal process of reproduction, as well as preventing the development of sexual infections and development of gynecological cancer.
    Lactobacillus Crispatus acts by inhibiting proinflammatory molecules. It also favors the production of certain interleukins such as IL-8, and regulates the innate epithelial immunity of the vaginal mucosa specifically. This allows additional protection of the function of the vaginal epithelium, especially in the presence of feminine hygiene products that alter the balance of this mucosa. In this way a specific immunity is conferred on the host of these probiotics.
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    The food supplement is formulated to be administered orally, therefore, it can be presented in the form of a capsule, tablet, granules, advantageously in the form of a capsule or envelope. If the food supplement is in the form of a soft capsule or capsule, the shell of said soft capsules or said capsules may contain
    5 especially animal gelatin, such as fish jelly, glycerin or a material of plant origin, such as a cellulose or starch derivative, or a vegetable protein. If the food supplement is in the form of a capsule, tablet or granulate, the active mixture can be fixed on a dusty support, such as silica, cellulose and maltodextrin.
    The food supplement of the invention preferably responds to the following weight composition:
    For a capsule / envelope
    -Mio-Inositol 1950 -2010 mg
    -D-Chiro-Inositol 195 -210 mg
    -Folic acid 0.1 - 0.2 mg
    15 -Selenium 0.08 -0.15 mg
    -Melatonin 0.5 - 1.1 mg
    -Lactobacillus Plantarum 5x1010 UFC
    -Lactobacillus Crispatus 5x1010 CFU
    -Lactobacillus Rhamnosus 5x1010 CFU
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    权利要求:
    Claims (1)
    [1]

    1st.- Food supplement for female fertility characterized in that it includes an association of:
    a) A mixture consisting of the isomers Mio-Inositol and D-Chiro-Inositol, Folic acid, 5 Selenium and Melatonin.
    b) A mixture of probiotic agents consisting of Lactobacillus Rhamnosus, Lactobacillus Plantarum and Lactobacillus Crispatus.
    2nd.- Food supplement for female fertility according to claim one characterized in that it comprises a capsule or envelope:
    10 -1950 -2010 mg of Mio-Inositol -195 -210 mg of D-Chiro-Inositol -0.1 - 0.2 mg of Folic acid -0.08 -0.15 mg of Selenium -0.5 - 1 , 1 mg of Melatonin
    15 -5x1010 CFU of Lactobacillus Plantarum -5x1010 CFU of Lactobacillus Crispatus -5x1010 CFU of
    3rd Use of the probiotics Lactobacillus Rhamnosus, Lactobacillus Plantarum and Lactobacillus Crispatus to prepare a food supplement for female fertility.
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    同族专利:
    公开号 | 公开日
    ES2550521B1|2016-09-06|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US20020044926A1|1999-12-10|2002-04-18|Gregor Reid|Oral administration of lactobacillus for the treatment and prevention of urogenital infection|
    US20100166721A1|2006-06-09|2010-07-01|Fabiola Masri|Probotic compositions and uses thereof|
    US20140205618A1|2012-12-28|2014-07-24|CortControl, Inc.|Human fertility enhancement with cortisol reduction food|CN109810991A|2019-03-02|2019-05-28|昆明理工大学|The purposes of dihydropteroate synthase gene folP|
    法律状态:
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    优先权:
    申请号 | 申请日 | 专利标题
    ES201531144A|ES2550521B1|2015-07-31|2015-07-31|Food supplement for female fertility|ES201531144A| ES2550521B1|2015-07-31|2015-07-31|Food supplement for female fertility|
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